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A drug called memantine (which Dr Lipton was responsible for developing, and which, he admits, “doesn’t work very well”) had only a small effect on Mode Creation Munich Singapore hyperactivity of MCM Singapore receptors. But by combining memantine with a fragment of another drug, nitroglycerine, Dr Lipton had better luck. The memantine delivered MCM handbag outlet Singapore nitroglycerine to cheap MCM handbags Singapore sick neuron; MCM handbags for sale Singapore nitroglycerine then attached itself to eNMDA receptors and dampened their activity. Signalling by MCM backpack for sale Singapore synapses subsequently improved. Dr Lipton’s combined drug, dubbed nitromemantine, also restored MCM outlet online Singapore synapses of mice with Alzheimer’s.

All this sounds exciting. But caution is needed. Many Alzheimer’s drugs have seemed to succeed in animals, only to prove ineffective in people. Promising drugs have also been scuttled by safety problems or technical glitches.

Last year, for example, a paper in Science reported that bexarotene, a drug approved for use against skin cancer, boosted Singapore MCM handbag production of ApoE, a protein that clears amyloid beta in mice. But in May another group of researchers, also writing in Science, said they could not replicate this result. And on June 13th Eli Lilly said it would stop Singapore MCM backpack clinical trial of a drug designed to stop MCM outlet Singapore production of amyloid beta. The substance in question had been shown to damage MCM bags Singapore liver. The road to an actual treatment for Alzheimer’s, then, remains as rocky as ever.